Research

M Perera, Siyu Huang, Sean Ong, Dean McKenzie, Adam Mirabelli, David C. Chen, Thilakavathi Chengodu, Declan G. Murphy, Michael S. Hofman, Nathan Lawrentschuk
Comparison of 18F-based PSMA radiotracers with [68Ga]Ga-PSMA-11 in PET/CT imaging of prostate cancer—a systematic review and meta-analysis
Huang, S., Ong, S., McKenzie, D. et al. Comparison of 18F-based PSMA radiotracers with [68Ga]Ga-PSMA-11 in PET/CT imaging of prostate cancer—a systematic review and meta-analysis. Prostate Cancer Prostatic Dis (2023)

This study critically reviews and compares the efficacy of Fluorine-18 (18F) and Gallium-68 (68Ga) labelled PSMA PET/CT radiotracers in the staging and diagnosis of prostate cancer.

The analysis, based on 24 studies, finds that [18F]DCFPyL has a similar lesion detection rate to [68Ga]Ga-PSMA-11 without an increase in false positives. [18F]PSMA-1007 shows a higher local lesion detection due to its excretion route but also has significant benign bone uptakes, making it less preferable.

The review concludes that there is insufficient evidence to definitively favour one radiotracer over the other based on clinical impact.

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Dr. Marlon Perera

Dr. Marlon Perera is an Australian-trained, award-winning urology surgeon who specialises in robotic surgery and uro-oncology. Dr. Perera has worldwide experience, having completed a PhD (Urology) and a prized-accredited ‘Society of Urologic Oncology’ (SUO) fellowship at one of the world’s best and most prestigious cancer centres – Memorial Sloan Kettering Cancer Center in New York City. He provides comprehensive care in the treatment of prostate cancer, kidney masses and cancers, bladder cancer, kidney stones, and voiding dysfunction.